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Page 1
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs.
Rathinaswamy MK, Jenkins ML, Duewell BR, Zhang X, Harris NJ, Evans JT, Stariha JTB, Dalwadi U, Fleming KD, Ranga-Prasad H, Yip CK, Williams RL, Hansen SD, Burke JE. Rathinaswamy MK, et al. Among authors: fleming kd. Cell Rep. 2023 Mar 28;42(3):112172. doi: 10.1016/j.celrep.2023.112172. Epub 2023 Feb 26. Cell Rep. 2023. PMID: 36842083 Free PMC article.
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein L, Hornegger H, Anrather D, Hartl M, Fleming KD, Stariha JTB, Pardon E, Steyaert J, Burke JE, Leonard TA. Truebestein L, et al. Among authors: fleming kd. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2101496118. doi: 10.1073/pnas.2101496118. Proc Natl Acad Sci U S A. 2021. PMID: 34385319 Free PMC article.
The middle lipin domain adopts a membrane-binding dimeric protein fold.
Gu W, Gao S, Wang H, Fleming KD, Hoffmann RM, Yang JW, Patel NM, Choi YM, Burke JE, Reue K, Airola MV. Gu W, et al. Among authors: fleming kd. Nat Commun. 2021 Aug 5;12(1):4718. doi: 10.1038/s41467-021-24929-5. Nat Commun. 2021. PMID: 34354069 Free PMC article.
12 results